> Detailanzeige

Van Allen, Eliezer M.; Miao, Diana; Schilling, Bastian; Shukla, Sachet A.; Blank, Christian; Zimmer, Lisa; Sucker, Antje; Hillen, Uwe; Geukes Foppen, Marnix H.; Goldinger, Simone M.; Utikal, Jochen; Hassel, Jessica C.; Weide, Benjamin; Kaehler, Katharina C.; Loquai, Carmen; Mohr, Peter; Gutzmer, Ralf; Dummer, Reinhard; Gabriel, Stacey; Wu, Catherine J.; Schadendorf, Dirk; Garraway, Levi A.

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
  • Beteiligte: Van Allen, Eliezer M.; Miao, Diana; Schilling, Bastian; Shukla, Sachet A.; Blank, Christian; Zimmer, Lisa; Sucker, Antje; Hillen, Uwe; Geukes Foppen, Marnix H.; Goldinger, Simone M.; Utikal, Jochen; Hassel, Jessica C.; Weide, Benjamin; Kaehler, Katharina C.; Loquai, Carmen; Mohr, Peter; Gutzmer, Ralf; Dummer, Reinhard; Gabriel, Stacey; Wu, Catherine J.; Schadendorf, Dirk; Garraway, Levi A.
  • Erschienen: American Association for the Advancement of Science (AAAS), 2015
  • Erschienen in: Science
  • Sprache: Englisch
  • DOI: 10.1126/science.aad0095
  • ISSN: 0036-8075; 1095-9203
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Is cancer immunotherapy a private affair?</jats:title> <jats:p> Immune checkpoint blockade, a relatively new cancer treatment, substantially extends the survival of a subset of patients. Previous work has shown that patients whose tumors harbor the largest number of mutations—and thus produce a large number of “neoantigens” recognized as foreign by the immune system—are most likely to benefit. Expanding on these earlier studies, Van Allen <jats:italic>et al.</jats:italic> studied over 100 patients with melanoma and found a similar correlation (see the Perspective by Gubin and Schreiber). There was no evidence, however, that specific neoantigen sequences were shared by patients who responded. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6257" page="207" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aad0095">207</jats:related-article> , see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6257" page="158" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aad4140">158</jats:related-article> </jats:p>