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Medientyp:
E-Artikel
Titel:
Cotranslational protein folding on the ribosome monitored in real time
Beteiligte:
Holtkamp, Wolf;
Kokic, Goran;
Jäger, Marcus;
Mittelstaet, Joerg;
Komar, Anton A.;
Rodnina, Marina V.
Erschienen:
American Association for the Advancement of Science (AAAS), 2015
Erschienen in:Science
Sprache:
Englisch
DOI:
10.1126/science.aad0344
ISSN:
0036-8075;
1095-9203
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Proteins shape up in the ribosome</jats:title>
<jats:p>
Proteins consist of linear chains of amino acids. These chains must fold into complex three-dimensional shapes to become functional. Holtkamp
<jats:italic>et al.</jats:italic>
“watched” how a small helical protein folds as it is being synthesized by the ribosome. The lengthening polypeptide passes out through the ribosome exit tunnel where folding starts. The initially compact structure quickly rearranges into a native three-dimensional structure as the polypeptide emerges from the tunnel.
</jats:p>
<jats:p>
<jats:italic>Science</jats:italic>
, this issue p.
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