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Bidinosti, Michael; Botta, Paolo; Krüttner, Sebastian; Proenca, Catia C.; Stoehr, Natacha; Bernhard, Mario; Fruh, Isabelle; Mueller, Matthias; Bonenfant, Debora; Voshol, Hans; Carbone, Walter; Neal, Sarah J.; McTighe, Stephanie M.; Roma, Guglielmo; Dolmetsch, Ricardo E.; Porter, Jeffrey A.; Caroni, Pico; Bouwmeester, Tewis; Lüthi, Andreas; Galimberti, Ivan

CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency

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  • Medientyp: E-Artikel
  • Titel: CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency
  • Beteiligte: Bidinosti, Michael; Botta, Paolo; Krüttner, Sebastian; Proenca, Catia C.; Stoehr, Natacha; Bernhard, Mario; Fruh, Isabelle; Mueller, Matthias; Bonenfant, Debora; Voshol, Hans; Carbone, Walter; Neal, Sarah J.; McTighe, Stephanie M.; Roma, Guglielmo; Dolmetsch, Ricardo E.; Porter, Jeffrey A.; Caroni, Pico; Bouwmeester, Tewis; Lüthi, Andreas; Galimberti, Ivan
  • Erschienen: American Association for the Advancement of Science (AAAS), 2016
  • Erschienen in: Science
  • Sprache: Englisch
  • DOI: 10.1126/science.aad5487
  • ISSN: 0036-8075; 1095-9203
  • Schlagwörter: Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Signal problems in autism spectrum disorder</jats:title> <jats:p> Autism spectrum disorders have many causes. Bidinosti <jats:italic>et al.</jats:italic> studied Phelan-McDermid syndrome (PMDS), one of the symptoms of which can be autism (see the Perspective by Burbach). The authors used neurons derived from these patients, as well as from mice, with the culprit gene disrupted and found that a chain of intracellular signals becomes imbalanced. Signaling and behavioral symptoms could be improved by a small-molecule therapeutic that inhibits a key kinase. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6278" page="1199" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad5487">1199</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6278" page="1153" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aaf5097">1153</jats:related-article> </jats:p>