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Legoux, François; Bellet, Déborah; Daviaud, Celine; El Morr, Yara; Darbois, Aurelie; Niort, Kristina; Procopio, Emanuele; Salou, Marion; Gilet, Jules; Ryffel, Bernhard; Balvay, Aurélie; Foussier, Anne; Sarkis, Manal; El Marjou, Ahmed; Schmidt, Frederic; Rabot, Sylvie; Lantz, Olivier

Microbial metabolites control the thymic development of mucosal-associated invariant T cells

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  • Medientyp: E-Artikel
  • Titel: Microbial metabolites control the thymic development of mucosal-associated invariant T cells
  • Beteiligte: Legoux, François; Bellet, Déborah; Daviaud, Celine; El Morr, Yara; Darbois, Aurelie; Niort, Kristina; Procopio, Emanuele; Salou, Marion; Gilet, Jules; Ryffel, Bernhard; Balvay, Aurélie; Foussier, Anne; Sarkis, Manal; El Marjou, Ahmed; Schmidt, Frederic; Rabot, Sylvie; Lantz, Olivier
  • Erschienen: American Association for the Advancement of Science (AAAS), 2019
  • Erschienen in: Science
  • Sprache: Englisch
  • DOI: 10.1126/science.aaw2719
  • ISSN: 0036-8075; 1095-9203
  • Entstehung:
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  • Beschreibung: <jats:title>Commensals rule the MAITrix</jats:title> <jats:p> Mucosal-associated invariant T (MAIT) cells play an important role in mucosal homeostasis. MAIT cells recognize microbial small molecules presented by the major histocompatibility complex class Ib molecule MR1. MAIT cells are absent in germ-free mice, and the mechanisms by which microbiota control MAIT cell development are unknown (see the Perspective by Oh and Unutmaz). Legoux <jats:italic>et al.</jats:italic> show that, in mice, development of MAIT cells within the thymus is governed by the bacterial product 5-(2-oxopropylideneamino)-6- <jats:sc>d</jats:sc> -ribitylaminouracil, which rapidly traffics from the mucosa to the thymus, where it is captured by MR1 and presented to developing MAIT cells. Constantinides <jats:italic>et al.</jats:italic> report that MAIT cell induction only occurs during a limited, early-life window and requires exposure to defined microbes that produce riboflavin derivatives. Continual interactions between MAIT cells and commensals in the skin modulates tissue repair functions. Together, these papers highlight how the microbiota can direct immune cell development and subsequent function at mucosal sites by secreting compounds that act like self-antigens. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6464" page="494" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaw2719">494</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aax6624">eaax6624</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6464" page="419" related-article-type="in-this-issue" vol="366" xlink:href="10.1126/science.aaz4014">419</jats:related-article> </jats:p>