• Medientyp: E-Artikel
  • Titel: Developmental and evolutionary dynamics of cis-regulatory elements in mouse cerebellar cells
  • Beteiligte: Sarropoulos, Ioannis; Sepp, Mari; Frömel, Robert; Leiss, Kevin; Trost, Nils; Leushkin, Evgeny; Okonechnikov, Konstantin; Joshi, Piyush; Giere, Peter; Kutscher, Lena M.; Cardoso-Moreira, Margarida; Pfister, Stefan M.; Kaessmann, Henrik
  • Erschienen: American Association for the Advancement of Science (AAAS), 2021
  • Erschienen in: Science, 373 (2021) 6558
  • Sprache: Englisch
  • DOI: 10.1126/science.abg4696
  • ISSN: 0036-8075; 1095-9203
  • Schlagwörter: Multidisciplinary
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  • Anmerkungen:
  • Beschreibung: <jats:title>The cerebellum reveals its genetic programs</jats:title> <jats:p> Gene-regulatory networks govern the development of organs. Sarropoulos <jats:italic>et al</jats:italic> . analyzed mouse cerebellar development in the context of gene-regulatory networks. Single nuclear profiles analyzing chromatin accessibility in about 90,000 cells revealed diversity in progenitor cells and genetic programs guiding cellular differentiation. The footsteps of evolution were apparent in varying constraints on different cell types. —PJH </jats:p>