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Klomp, Jennifer E.; Diehl, J. Nathaniel; Klomp, Jeffrey A.; Edwards, A. Cole; Yang, Runying; Morales, Alexis J.; Taylor, Khalilah E.; Drizyte-Miller, Kristina; Bryant, Kirsten L.; Schaefer, Antje; Johnson, Jared L.; Huntsman, Emily M.; Yaron, Tomer M.; Pierobon, Mariaelena; Baldelli, Elisa; Prevatte, Alex W.; Barker, Natalie K.; Herring, Laura E.; Petricoin, Emanuel F.; Graves, Lee M.; Cantley, Lewis C.; Cox, Adrienne D.; Der, Channing J.; Stalnecker, Clint A.

Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer

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  • Medientyp: E-Artikel
  • Titel: Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
  • Beteiligte: Klomp, Jennifer E.; Diehl, J. Nathaniel; Klomp, Jeffrey A.; Edwards, A. Cole; Yang, Runying; Morales, Alexis J.; Taylor, Khalilah E.; Drizyte-Miller, Kristina; Bryant, Kirsten L.; Schaefer, Antje; Johnson, Jared L.; Huntsman, Emily M.; Yaron, Tomer M.; Pierobon, Mariaelena; Baldelli, Elisa; Prevatte, Alex W.; Barker, Natalie K.; Herring, Laura E.; Petricoin, Emanuel F.; Graves, Lee M.; Cantley, Lewis C.; Cox, Adrienne D.; Der, Channing J.; Stalnecker, Clint A.
  • Erschienen: American Association for the Advancement of Science (AAAS), 2024
  • Erschienen in: Science, 384 (2024) 6700
  • Sprache: Englisch
  • DOI: 10.1126/science.adk0850
  • ISSN: 0036-8075; 1095-9203
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: To delineate the mechanisms by which the ERK1 and ERK2 mitogen-activated protein kinases support mutant KRAS–driven cancer growth, we determined the ERK-dependent phosphoproteome in KRAS-mutant pancreatic cancer. We determined that ERK1 and ERK2 share near-identical signaling and transforming outputs and that the KRAS-regulated phosphoproteome is driven nearly completely by ERK. We identified 4666 ERK-dependent phosphosites on 2123 proteins, of which 79 and 66%, respectively, were not previously associated with ERK, substantially expanding the depth and breadth of ERK-dependent phosphorylation events and revealing a considerably more complex function for ERK in cancer. We established that ERK controls a highly dynamic and complex phosphoproteome that converges on cyclin-dependent kinase regulation and RAS homolog guanosine triphosphatase function (RHO GTPase). Our findings establish the most comprehensive molecular portrait and mechanisms by which ERK drives KRAS-dependent pancreatic cancer growth.