Beschreibung:
<jats:title>ABSTRACT</jats:title>
<jats:p>
Among 203 strains of
<jats:italic>Staphylococcus aureus</jats:italic>
, the MICs of CG400549 were 0.06 to 1.0 μg/ml, with MIC
<jats:sub>50</jats:sub>
and MIC
<jats:sub>90</jats:sub>
values of 0.25 μg/ml each. All strains were susceptible to linezolid and quinupristin-dalfopristin (MICs, 0.25 to 2.0 μg/ml). The daptomycin MICs were 0.25 to 2.0 μg/ml for methicillin-susceptible and 0.25 to 4.0 μg/ml against methicillin-resistant strains (including vancomycin-intermediate strains). Single-passage selection testing showed low resistance frequencies with CG400549, but multistep analysis showed that CG400549 yielded resistant mutants after 14 to 17 days in all strains tested.
</jats:p>