Roundtree, Mark T.;
Juvvadi, Praveen R.;
Shwab, E. Keats;
Cole, D. Christopher;
Steinbach, William J.
Aspergillus fumigatus Cyp51A and Cyp51B Proteins Are Compensatory in Function and Localize Differentially in Response to Antifungals and Cell Wall Inhibitors
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Medientyp:
E-Artikel
Titel:
Aspergillus fumigatus Cyp51A and Cyp51B Proteins Are Compensatory in Function and Localize Differentially in Response to Antifungals and Cell Wall Inhibitors
Beteiligte:
Roundtree, Mark T.;
Juvvadi, Praveen R.;
Shwab, E. Keats;
Cole, D. Christopher;
Steinbach, William J.
Erschienen:
American Society for Microbiology, 2020
Erschienen in:Antimicrobial Agents and Chemotherapy
Sprache:
Englisch
DOI:
10.1128/aac.00735-20
ISSN:
0066-4804;
1098-6596
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>
Triazole antifungals are the primary therapeutic option against invasive aspergillosis. However, resistance to azoles has increased dramatically over the last decade. Azole resistance is known to primarily occur due to point mutations in the azole target protein Cyp51A, one of two paralogous 14-α sterol demethylases found in
<jats:named-content content-type="genus-species">Aspergillus fumigatus</jats:named-content>
. Despite the importance of Cyp51A, little is known about the function of its paralog, Cyp51B, and the behavior of these proteins within the cell or their functional interrelationship.
</jats:p>