• Medientyp: E-Artikel
  • Titel: Biological, Biochemical, and Molecular Characterization of a New Clinical Trichophyton rubrum Isolate Resistant to Terbinafine
  • Beteiligte: Osborne, Colin S.; Leitner, Ingrid; Hofbauer, Bettina; Fielding, Ceri A.; Favre, Bertrand; Ryder, Neil S.
  • Erschienen: American Society for Microbiology, 2006
  • Erschienen in: Antimicrobial Agents and Chemotherapy
  • Sprache: Englisch
  • DOI: 10.1128/aac.01600-05
  • ISSN: 0066-4804; 1098-6596
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  • Beschreibung: <jats:title>ABSTRACT</jats:title> <jats:p> We have characterized a new clinical strain of <jats:italic>Trichophyton rubrum</jats:italic> highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L. </jats:p>
  • Zugangsstatus: Freier Zugang