Wire, Mary Beth;
Jun, Soo Youn;
Jang, In-Jin;
Lee, Seung-Hwan;
Hwang, Jun Gi;
Huang, David B.
A Phase 1 Study To Evaluate Safety and Pharmacokinetics following Administration of Single and Multiple Doses of the Antistaphylococcal Lysin LSVT-1701 in Healthy Adult Subjects
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Medientyp:
E-Artikel
Titel:
A Phase 1 Study To Evaluate Safety and Pharmacokinetics following Administration of Single and Multiple Doses of the Antistaphylococcal Lysin LSVT-1701 in Healthy Adult Subjects
Beteiligte:
Wire, Mary Beth;
Jun, Soo Youn;
Jang, In-Jin;
Lee, Seung-Hwan;
Hwang, Jun Gi;
Huang, David B.
Erschienen:
American Society for Microbiology, 2022
Erschienen in:Antimicrobial Agents and Chemotherapy
Beschreibung:
<jats:p>Thirty-two healthy male subjects (8 per cohort) were randomized 6:2 to active:placebo. LSVT-1701, an antistaphylococcal lysin, was administered intravenously as a 6-mg/kg single dose and as 1.5, 3, and 4.5 mg/kg twice daily for 4 days.</jats:p>