The Recombinant Bacteriophage Endolysin HY-133 Exhibits In Vitro Activity against Different African Clonal Lineages of the Staphylococcus aureus Complex, Including Staphylococcus schweitzeri
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Medientyp:
E-Artikel
Titel:
The Recombinant Bacteriophage Endolysin HY-133 Exhibits In Vitro Activity against Different African Clonal Lineages of the Staphylococcus aureus Complex, Including Staphylococcus schweitzeri
Beschreibung:
<jats:title>ABSTRACT</jats:title>
<jats:p>
HY-133 is a recombinant bacteriophage endolysin with bactericidal activity against
<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">Staphylococcus aureus</jats:named-content>
. Here, HY-133 showed
<jats:italic>in vitro</jats:italic>
activity against major African methicillin-susceptible and methicillin-resistant
<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">S. aureus</jats:named-content>
lineages and ceftaroline/ceftobiprole- and borderline oxacillin-resistant isolates. HY-133 was also active against
<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">Staphylococcus schweitzeri</jats:named-content>
, a recently described species of the
<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">S. aureus</jats:named-content>
complex. The activity of HY-133 on the tested isolates (MIC
<jats:sub>50</jats:sub>
, 0.25 μg/ml; MIC
<jats:sub>90</jats:sub>
, 0.5 μg/ml; range, 0.125 to 0.5 μg/ml) was independent of the species and strain background or antibiotic resistance.
</jats:p>