• Medientyp: E-Artikel
  • Titel: Activity of Glycopeptides against Staphylococcus aureus Infection in a Rabbit Endocarditis Model: MICs Do Not Predict In Vivo Efficacy
  • Beteiligte: Asseray, Nathalie; Jacqueline, Cedric; Le Mabecque, Virginie; Batard, Eric; Bugnon, Denis; Potel, Gilles; Caillon, Jocelyne
  • Erschienen: American Society for Microbiology, 2005
  • Erschienen in: Antimicrobial Agents and Chemotherapy
  • Sprache: Englisch
  • DOI: 10.1128/aac.49.2.857-859.2005
  • ISSN: 0066-4804; 1098-6596
  • Schlagwörter: Infectious Diseases ; Pharmacology (medical) ; Pharmacology
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  • Beschreibung: <jats:title>ABSTRACT</jats:title> <jats:p> The in vivo efficacy of vancomycin and teicoplanin against five <jats:italic>Staphylococcus aureus</jats:italic> strains with different susceptibilities to them and methicillin was studied. Rabbits were allocated at random to groups for endocarditis induction with one of these five strains and then treated for 2 days with vancomycin or teicoplanin. Each treated group was compared with a control group infected with the same strain. Vancomycin and teicoplanin showed similar activities. Low MICs did not predict better in vivo results. </jats:p>
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