Kosowska-Shick, Klaudia;
Clark, Catherine;
Credito, Kim;
McGhee, Pamela;
Dewasse, Bonifacio;
Bogdanovich, Tatiana;
Appelbaum, Peter C.
Single- and Multistep Resistance Selection Studies on the Activity of Retapamulin Compared to Other Agents against Staphylococcus aureus and Streptococcus pyogenes
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Medientyp:
E-Artikel
Titel:
Single- and Multistep Resistance Selection Studies on the Activity of Retapamulin Compared to Other Agents against Staphylococcus aureus and Streptococcus pyogenes
Beteiligte:
Kosowska-Shick, Klaudia;
Clark, Catherine;
Credito, Kim;
McGhee, Pamela;
Dewasse, Bonifacio;
Bogdanovich, Tatiana;
Appelbaum, Peter C.
Erschienen:
American Society for Microbiology, 2006
Erschienen in:Antimicrobial Agents and Chemotherapy
Sprache:
Englisch
DOI:
10.1128/aac.50.2.765-769.2006
ISSN:
0066-4804;
1098-6596
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>ABSTRACT</jats:title>
<jats:p>
Retapamulin had the lowest rate of spontaneous mutations by single-step passaging and the lowest parent and selected mutant MICs by multistep passaging among all drugs tested for all
<jats:italic>Staphylococcus aureus</jats:italic>
strains and three
<jats:italic>Streptococcus pyogenes</jats:italic>
strains which yielded resistant clones. Retapamulin has a low potential for resistance selection in
<jats:italic>S. pyogenes</jats:italic>
, with a slow and gradual propensity for resistance development in
<jats:italic>S. aureus</jats:italic>
.
</jats:p>