Neu, Anna Katrin;
Månsson, Maria;
Gram, Lone;
Prol-García, María J.
Toxicity of Bioactive and Probiotic Marine Bacteria and Their Secondary Metabolites in Artemia sp. and Caenorhabditis elegans as Eukaryotic Model Organisms
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Medientyp:
E-Artikel
Titel:
Toxicity of Bioactive and Probiotic Marine Bacteria and Their Secondary Metabolites in Artemia sp. and Caenorhabditis elegans as Eukaryotic Model Organisms
Beteiligte:
Neu, Anna Katrin;
Månsson, Maria;
Gram, Lone;
Prol-García, María J.
Erschienen:
American Society for Microbiology, 2014
Erschienen in:Applied and Environmental Microbiology
Beschreibung:
<jats:title>ABSTRACT</jats:title>
<jats:p>
We have previously reported that some strains belonging to the marine
<jats:named-content content-type="genus-species">Actinobacteria</jats:named-content>
class, the
<jats:named-content content-type="genus-species">Pseudoalteromonas</jats:named-content>
genus, the
<jats:named-content content-type="genus-species">Roseobacter</jats:named-content>
clade, and the
<jats:named-content content-type="genus-species">Photobacteriaceae</jats:named-content>
and
<jats:named-content content-type="genus-species">Vibrionaceae</jats:named-content>
families produce both antibacterial and antivirulence compounds, and these organisms are interesting from an applied point of view as fish probiotics or as a source of pharmaceutical compounds. The application of either organisms or compounds requires that they do not cause any side effects, such as toxicity in eukaryotic organisms. The purpose of this study was to determine whether these bacteria or their compounds have any toxic side effects in the eukaryotic organisms
<jats:named-content content-type="genus-species">Artemia</jats:named-content>
sp. and
<jats:named-content content-type="genus-species">Caenorhabditis elegans</jats:named-content>
.
<jats:named-content content-type="genus-species">Arthrobacter davidanieli</jats:named-content>
WX-11,
<jats:named-content content-type="genus-species">Pseudoalteromonas luteoviolacea</jats:named-content>
S4060,
<jats:named-content content-type="genus-species">P. piscicida</jats:named-content>
S2049,
<jats:named-content content-type="genus-species">P. rubra</jats:named-content>
S2471,
<jats:named-content content-type="genus-species">Photobacterium halotolerans</jats:named-content>
S2753, and
<jats:named-content content-type="genus-species">Vibrio coralliilyticus</jats:named-content>
S2052 were lethal to either or both model eukaryotes. The toxicity of
<jats:named-content content-type="genus-species">P. luteoviolacea</jats:named-content>
S4060 could be related to the production of the antibacterial compound pentabromopseudilin, while the adverse effect observed in the presence of
<jats:named-content content-type="genus-species">P. halotolerans</jats:named-content>
S2753 and
<jats:named-content content-type="genus-species">V. coralliilyticus</jats:named-content>
S2052 could not be explained by the production of holomycin nor andrimid, the respective antibiotic compounds in these organisms. In contrast, the tropodithietic acid (TDA)-producing bacteria
<jats:named-content content-type="genus-species">Phaeobacter inhibens</jats:named-content>
DSM17395 and
<jats:named-content content-type="genus-species">Ruegeria mobilis</jats:named-content>
F1926 and TDA itself had no adverse effect on the target organisms. These results reaffirm TDA-producing
<jats:named-content content-type="genus-species">Roseobacter</jats:named-content>
bacteria as a promising group to be used as probiotics in aquaculture, whereas
<jats:named-content content-type="genus-species">Actinobacteria</jats:named-content>
,
<jats:named-content content-type="genus-species">Pseudoalteromonas</jats:named-content>
,
<jats:named-content content-type="genus-species">Photobacteriaceae</jats:named-content>
, and
<jats:named-content content-type="genus-species">Vibrionaceae</jats:named-content>
should be used with caution.
</jats:p>