Comprehensive Study of Strains Previously Designated Streptococcus bovis Consecutively Isolated from Human Blood Cultures and Emended Description of Streptococcus gallolyticus and Streptococcus infantarius subsp. coli
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Titel:
Comprehensive Study of Strains Previously Designated Streptococcus bovis Consecutively Isolated from Human Blood Cultures and Emended Description of Streptococcus gallolyticus and Streptococcus infantarius subsp. coli
Beschreibung:
<jats:title>ABSTRACT</jats:title>
<jats:p>
Modern taxonomy has delineated
<jats:italic>Streptococcus gallolyticus</jats:italic>
subsp.
<jats:italic>gallolyticus</jats:italic>
,
<jats:italic>S. gallolyticus</jats:italic>
subsp.
<jats:italic>pasteurianus</jats:italic>
,
<jats:italic>Streptococcus infantarius</jats:italic>
subsp.
<jats:italic>coli</jats:italic>
, and
<jats:italic>S. infantarius</jats:italic>
subsp.
<jats:italic>infantarius</jats:italic>
within the heterogenous group of previously designated clinical
<jats:italic>Streptococcus bovis</jats:italic>
bacteria. In the present study, 58 consecutive blood culture isolates initially designated
<jats:italic>S. bovis</jats:italic>
were further characterized by applying phenotypic and molecular genetic methods, and possible disease associations were investigated by studying the patients' records. Published phenotypic characteristics of
<jats:italic>S. gallolyticus</jats:italic>
and
<jats:italic>S. infantarius</jats:italic>
were not unequivocal and did not allow an unambiguous phenotypic differentiation of the 58 clinical isolates. However, full-length 16S rRNA gene sequences clearly assigned the strains to
<jats:italic>S. gallolyticus</jats:italic>
subsp.
<jats:italic>gallolyticus</jats:italic>
(
<jats:italic>n</jats:italic>
= 29),
<jats:italic>S. gallolyticus</jats:italic>
subsp.
<jats:italic>pasteurianus</jats:italic>
(
<jats:italic>n</jats:italic>
= 12), and
<jats:italic>S. infantarius</jats:italic>
subsp.
<jats:italic>coli</jats:italic>
(
<jats:italic>n</jats:italic>
= 17). Only 28% of the patients with available records presented with endocarditis and 7% presented with colon carcinoma, whereas 37% of the patients had altered liver parenchyma and 28% had gall bladder disease as underlying diseases. Detailed antimicrobial susceptibility data on both
<jats:italic>S. gallolyticus</jats:italic>
subspecies and
<jats:italic>S. infantarius</jats:italic>
subsp.
<jats:italic>coli</jats:italic>
are given for the first time. As a result of the extensive characterization of the largest number of
<jats:italic>S. gallolyticus</jats:italic>
and
<jats:italic>S. infantarius</jats:italic>
human clinical isolates published so far, emended species descriptions are given. It is recommended that both clinical microbiologists and infectious disease specialists avoid the designation
<jats:italic>S. bovis</jats:italic>
for true
<jats:italic>S. gallolyticus</jats:italic>
and
<jats:italic>S. infantarius</jats:italic>
strains in the future in order to get a clearer picture of the possible disease associations of these species.
</jats:p>