Beschreibung:
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Elevation of Ap
<jats:sub>4</jats:sub>
A level in bacteria is associated with increased sensitivity to heat and oxidative stress, reduced antibiotic tolerance, and decreased pathogenicity. ApaH is the major Ap
<jats:sub>4</jats:sub>
A hydrolase in gamma- and betaproteobacteria and has been recently proposed as a novel target to weaken the bacterial resistance to antibiotics. Here, we identified the orphan YqeK protein family (COG1713) as a highly efficient Ap
<jats:sub>4</jats:sub>
A hydrolase family, with members distributed in a consistent group of bacterial species that lack the ApaH enzyme. Among them are the pathogens
<jats:named-content content-type="genus-species">Staphylococcus aureus</jats:named-content>
,
<jats:named-content content-type="genus-species">Streptococcus pneumoniae</jats:named-content>
, and
<jats:named-content content-type="genus-species">Mycoplasma pneumoniae</jats:named-content>
. By identifying the player contributing to Ap
<jats:sub>4</jats:sub>
A homeostasis in these bacteria, we disclose a novel target to develop innovative antibacterial strategies.
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