Erschienen:
American Society for Microbiology, 1998
Erschienen in:Journal of Bacteriology
Sprache:
Englisch
DOI:
10.1128/jb.180.5.1323-1330.1998
ISSN:
0021-9193;
1098-5530
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>ABSTRACT</jats:title>
<jats:p>
The sequence diversity of 45 Opa outer membrane proteins from
<jats:italic>Neisseria meningitidis</jats:italic>
,
<jats:italic>Neisseria gonorrhoeae</jats:italic>
,
<jats:italic>Neisseria sicca</jats:italic>
, and
<jats:italic>Neisseria flava</jats:italic>
indicates that horizontal genetic exchange of
<jats:italic>opa</jats:italic>
alleles has been rare between these species. A two-dimensional structural model containing four surface-exposed loops was constructed based on rules derived from porin crystal structure and on conservation of sequence homology within transmembrane β-strands. The minimal continuous epitopes recognized by 23 monoclonal antibodies were mapped to loops 2 and 3. Some of these epitopes are localized on the bacterial cell surface, in support of the model.
</jats:p>