Slyker, Jennifer A.;
Rowland-Jones, Sarah L.;
Dong, Tao;
Reilly, Marie;
Richardson, Barbra;
Emery, Vincent C.;
Atzberger, Ann;
Mbori-Ngacha, Dorothy;
Lohman-Payne, Barbara L.;
John-Stewart, Grace C.
Acute Cytomegalovirus Infection Is Associated with Increased Frequencies of Activated and Apoptosis-Vulnerable T Cells in HIV-1-Infected Infants
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Medientyp:
E-Artikel
Titel:
Acute Cytomegalovirus Infection Is Associated with Increased Frequencies of Activated and Apoptosis-Vulnerable T Cells in HIV-1-Infected Infants
Beteiligte:
Slyker, Jennifer A.;
Rowland-Jones, Sarah L.;
Dong, Tao;
Reilly, Marie;
Richardson, Barbra;
Emery, Vincent C.;
Atzberger, Ann;
Mbori-Ngacha, Dorothy;
Lohman-Payne, Barbara L.;
John-Stewart, Grace C.
Erschienen:
American Society for Microbiology, 2012
Beschreibung:
<jats:title>ABSTRACT</jats:title><jats:p>Cytomegalovirus (CMV) coinfection is associated with infant HIV-1 disease progression and mortality. In a cohort of Kenyan HIV-infected infants, the frequencies of activated (CD38<jats:sup>+</jats:sup>HLA-DR<jats:sup>+</jats:sup>) and apoptosis-vulnerable (CD95<jats:sup>+</jats:sup>Bcl-2<jats:sup>−</jats:sup>) CD4<jats:sup>+</jats:sup>and CD8<jats:sup>+</jats:sup>T cells increased substantially during acute CMV infection. The frequency of activated CD4<jats:sup>+</jats:sup>T cells was strongly associated with both concurrent CMV coinfection (<jats:italic>P</jats:italic>= 0.001) and HIV-1 viral load (<jats:italic>P</jats:italic>= 0.05). The frequency of apoptosis-vulnerable cells was also associated with CMV coinfection in the CD4 (<jats:italic>P</jats:italic>= 0.02) and CD8 (<jats:italic>P</jats:italic>< 0.001) T cell subsets. Similar observations were made in HIV-exposed uninfected infants. CMV-induced increases in T cell activation and apoptosis may contribute to the rapid disease progression in coinfected infants.</jats:p>