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Medientyp:
E-Artikel
Titel:
CD4 Binding Affinity Determines Human Immunodeficiency Virus Type 1-Induced Alpha Interferon Production in Plasmacytoid Dendritic Cells
Beteiligte:
Haupt, Sabrina;
Donhauser, Norbert;
Chaipan, Chawaree;
Schuster, Philipp;
Puffer, Bridget;
Daniels, Rod S.;
Greenough, Thomas C.;
Kirchhoff, Frank;
Schmidt, Barbara
Erschienen:
American Society for Microbiology, 2008
Erschienen in:
Journal of Virology, 82 (2008) 17, Seite 8900-8905
Sprache:
Englisch
DOI:
10.1128/jvi.00196-08
ISSN:
0022-538X;
1098-5514
Entstehung:
Anmerkungen:
Beschreibung:
ABSTRACTPlasmacytoid dendritic cells (PDC) are major producers of type I interferons (IFN) in response to human immunodeficiency virus type 1 (HIV-1) infection. To better define the underlying mechanisms, we studied the magnitude of alpha IFN (IFN-α) induction by recombinant viruses containing changes in the Env protein that impair or disrupt CD4 binding or expressing primaryenvalleles with differential coreceptor tropism. We found that the CD4 binding affinity but not the viral coreceptor usage is critical for the attachment of autofluorescing HIV-1 to PDC and for subsequent IFN-α induction. Our results illustrate the importance of the gp120-CD4 interaction in determining HIV-1-induced immune stimulation via IFN-α production.