Labyrinthopeptins Exert Broad-Spectrum Antiviral Activity through Lipid-Binding-Mediated Virolysis

Medientyp: E-Artikel

Titel: Labyrinthopeptins Exert Broad-Spectrum Antiviral Activity through Lipid-Binding-Mediated Virolysis

Beteiligte: Prochnow, Hans; Rox, Katharina; Birudukota, N. V. Suryanarayana; Weichert, Loreen; Hotop, Sven-Kevin; Klahn, Philipp; Mohr, Kathrin; Franz, Sergej; Banda, Dominic H.; Blockus, Sebastian; Schreiber, Janine; Haid, Sibylle; Oeyen, Merel; Martinez, Javier P.; Süssmuth, Roderich D.; Wink, Joachim; Meyerhans, Andreas; Goffinet, Christine; Messerle, Martin; Schulz, Thomas F.; Kröger, Andrea; Schols, Dominique; Pietschmann, Thomas; Brönstrup, Mark

Erschienen: American Society for Microbiology, 2020

Sprache: Englisch

DOI: 10.1128/jvi.01471-19

ISSN: 1098-5514; 0022-538X

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Beschreibung: For many viral infections, current treatment options are insufficient. Because the development of each antiviral drug is time-consuming and expensive, the prospect of finding broad-spectrum antivirals that can fight multiple, diverse viruses—well-known viruses as well as (re)emerging species—has gained attention, especially for the treatment of viral coinfections. While most known broad-spectrum agents address processes in the host cell, we found that targeting lipids of the free virus outside the host cell with the natural products labyrinthopeptin A1 and A2 is a viable strategy to inhibit the proliferation of a broad range of viruses from different families, including chikungunya virus, dengue virus, Zika virus, Kaposi’s sarcoma-associated herpesvirus, and cytomegalovirus. Labyrinthopeptins bind to viral phosphatidylethanolamine and induce virolysis without exerting cytotoxicity on host cells. This represents a novel and unusual mechanism to tackle medically relevant viral infections.

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