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Medientyp:
E-Artikel
Titel:
Chromosomal organization of the herpes simplex virus genome during acute infection of the mouse central nervous system
Beteiligte:
Muggeridge, M I;
Fraser, N W
Erschienen:
American Society for Microbiology, 1986
Erschienen in:Journal of Virology
Sprache:
Englisch
DOI:
10.1128/jvi.59.3.764-767.1986
ISSN:
0022-538X;
1098-5514
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>After corneal inoculation, herpes simplex virus type 1 replicates in the mouse eye, trigeminal ganglia, and brainstem, producing first an acute and then a latent infection. Previous work from this laboratory focused on the structure of the viral DNA in this system. We have now examined the structure of the viral genome at the chromosome level by using micrococcal nuclease digestion. Studies with disaggregated cell preparations made from the brainstems of acutely infected mice show that the majority of the viral DNA is in a nonnucleosomal form; however, a nucleosomelike fraction was also consistently detected. A similar result was obtained for viral DNA in herpes simplex virus type 1-infected C1300 (clone NA) neuroblastoma cells (a neuronal cell line).</jats:p>