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Medientyp:
E-Artikel
Titel:
An Antiviral Compound That Blocks Structural Transitions of Poliovirus Prevents Receptor Binding at Low Temperatures
Beteiligte:
Dove, Alan W.;
Racaniello, Vincent R.
Erschienen:
American Society for Microbiology, 2000
Erschienen in:Journal of Virology
Sprache:
Englisch
DOI:
10.1128/jvi.74.8.3929-3931.2000
ISSN:
0022-538X;
1098-5514
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>ABSTRACT</jats:title>
<jats:p>Drugs such as WIN51711 that inhibit picornavirus replication are thought to block poliovirus infectivity by binding to the capsid and preventing structural transitions required for uncoating. We examined the activity of WIN51711 at temperatures where capsid flexibility is thought to be decreased. Below 37°C, WIN51711 inhibits the binding of wild-type poliovirus to cells but does not affect the binding of a poliovirus mutant which is believed to undergo structural transitions more readily. These results suggest that the poliovirus capsid must undergo structural changes to bind to its cellular receptor.</jats:p>