Dosch, Tanja;
Horn, Florian;
Schneider, Grit;
Krätzer, Friedrich;
Dobner, Thomas;
Hauber, Joachim;
Stauber, Roland H.
The Adenovirus Type 5 E1B-55K Oncoprotein Actively Shuttles in Virus-Infected Cells, Whereas Transport of E4orf6 Is Mediated by a CRM1-Independent Mechanism
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Medientyp:
E-Artikel
Titel:
The Adenovirus Type 5 E1B-55K Oncoprotein Actively Shuttles in Virus-Infected Cells, Whereas Transport of E4orf6 Is Mediated by a CRM1-Independent Mechanism
Beteiligte:
Dosch, Tanja;
Horn, Florian;
Schneider, Grit;
Krätzer, Friedrich;
Dobner, Thomas;
Hauber, Joachim;
Stauber, Roland H.
Erschienen:
American Society for Microbiology, 2001
Beschreibung:
<jats:title>ABSTRACT</jats:title>
<jats:p>The E1B-55K and E4orf6 proteins of adenovirus type 5 are involved in viral mRNA export. Here we demonstrate that adenovirus infection does not inhibit the function of the E1B-55K nuclear export signal and that E1B-55K also shuttles in infected cells. Even during virus infection, E1B-55K was exported by the leptomycin B-sensitive CRM1 pathway, whereas E4orf6 transport appeared to be mediated by an alternative mechanism. Our results strengthen the potential role of E1B-55K as the “driving force” for adenoviral late mRNA export.</jats:p>