Relative Dominance of Gag p24-Specific Cytotoxic T Lymphocytes Is Associated with Human Immunodeficiency Virus Control

Medientyp: E-Artikel

Titel: Relative Dominance of Gag p24-Specific Cytotoxic T Lymphocytes Is Associated with Human Immunodeficiency Virus Control

Beteiligte: Zuñiga, Rosario; Lucchetti, Aldo; Galvan, Patricia; Sanchez, Shyla; Sanchez, Carmen; Hernandez, Ana; Sanchez, Hugo; Frahm, Nicole; Linde, Caitlyn H.; Hewitt, Hannah S.; Hildebrand, William; Altfeld, Marcus; Allen, Todd M.; Walker, Bruce D.; Korber, Bette T.; Leitner, Thomas; Sanchez, Jorge; Brander, Christian

Erschienen: American Society for Microbiology, 2006

Sprache: Englisch

DOI: 10.1128/jvi.80.6.3122-3125.2006

ISSN: 1098-5514; 0022-538X

Entstehung:

Anmerkungen:

Beschreibung: ABSTRACT Conflicting data on the role of total virus- and protein-specific cytotoxic-T-lymphocyte (CTL) responses in the control of human immunodeficiency virus (HIV) disease progression exist. We present data generated from a Peruvian cohort of untreated, clade B-infected subjects, demonstrating that the proportion of Gag-specific, and in particular p24-reactive, CTL responses among the total virus-specific CTL activity is associated with individuals' CD4 counts and viral loads. Analyses in a second cohort in the United States confirm these findings and point towards a dominant role of Gag-specific immunity in effective control of HIV infection, providing important guidance for HIV vaccine development.

Zugangsstatus: Freier Zugang

Nur in Feld suchen:

Zuletzt gesuchte Begriffe: