Ahr1 and Tup1 Contribute to the Transcriptional Control of Virulence-Associated Genes in Candida albicans

Medientyp: E-Artikel
Titel: Ahr1 and Tup1 Contribute to the Transcriptional Control of Virulence-Associated Genes in Candida albicans
Beteiligte: Ruben, Sophia; Garbe, Enrico; Mogavero, Selene; Albrecht-Eckardt, Daniela; Hellwig, Daniela; Häder, Antje; Krüger, Thomas; Gerth, Katrin; Jacobsen, Ilse D.; Elshafee, Osama; Brunke, Sascha; Hünniger, Kerstin; Kniemeyer, Olaf; Brakhage, Axel A.; Morschhäuser, Joachim; Hube, Bernhard; Vylkova, Slavena; Kurzai, Oliver; Martin, Ronny
Erschienen: American Society for Microbiology, 2020
Erschienen in: mBio
Sprache: Englisch
DOI: 10.1128/mbio.00206-20
ISSN: 2161-2129; 2150-7511
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Beschreibung: <jats:p> <jats:named-content content-type="genus-species">Candida albicans</jats:named-content> is a major human fungal pathogen and the leading cause of systemic <jats:italic>Candida</jats:italic> infections. In recent years, Als3 and Ece1 were identified as important factors for fungal virulence. Transcription of both corresponding genes is closely associated with hyphal growth. Here, we describe how Tup1, normally a global repressor of gene expression as well as of filamentation, and the transcription factor Ahr1 contribute to full expression of <jats:italic>ALS3</jats:italic> and <jats:italic>ECE1</jats:italic> in <jats:named-content content-type="genus-species">C. albicans</jats:named-content> hyphae. Both regulators are required for high mRNA amounts of the two genes to ensure functional relevant protein synthesis and localization. These observations identified a new aspect of regulation in the complex transcriptional control of virulence-associated genes in <jats:named-content content-type="genus-species">C. albicans</jats:named-content> . </jats:p>
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