• Medientyp: E-Artikel
  • Titel: Restructured Mitochondrial-Nuclear Interaction in Plasmodium falciparum Dormancy and Persister Survival after Artemisinin Exposure
  • Beteiligte: Connelly, Sean V.; Manzella-Lapeira, Javier; Levine, Zoë C.; Brzostowski, Joseph; Krymskaya, Ludmila; Rahman, Rifat S.; Ellis, Angela C.; Amin, Shuchi N.; Sá, Juliana M.; Wellems, Thomas E.
  • Erschienen: American Society for Microbiology, 2021
  • Erschienen in: mBio
  • Sprache: Englisch
  • DOI: 10.1128/mbio.00753-21
  • ISSN: 2150-7511
  • Schlagwörter: Virology ; Microbiology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p> The major first-line treatment for malaria, especially the deadliest form caused by <jats:named-content content-type="genus-species">Plasmodium falciparum</jats:named-content> , is combination therapy with an artemisinin-based drug (ART) plus a partner drug to assure complete cure. Without an effective partner drug, ART administration alone can fail because of the ability of small populations of blood-stage malaria parasites to enter into a dormant state and survive repeated treatments for a week or more. </jats:p>
  • Zugangsstatus: Freier Zugang