• Medientyp: E-Artikel
  • Titel: Greater Breadth of Vaccine-Induced Immunity in Females than Males Is Mediated by Increased Antibody Diversity in Germinal Center B Cells
  • Beteiligte: Ursin, Rebecca L.; Dhakal, Santosh; Liu, Hsuan; Jayaraman, Sahana; Park, Han-Sol; Powell, Harrison R.; Sherer, Morgan L.; Littlefield, Kirsten E.; Fink, Ashley L.; Ma, Zexu; Mueller, Alice L.; Chen, Allison P.; Seddu, Kumba; Woldetsadik, Yishak A.; Gearhart, Patricia J.; Larman, H. Benjamin; Maul, Robert W.; Pekosz, Andrew; Klein, Sabra L.
  • Erschienen: American Society for Microbiology, 2022
  • Erschienen in: mBio
  • Sprache: Englisch
  • DOI: 10.1128/mbio.01839-22
  • ISSN: 2150-7511
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>Adult females develop greater antibody responses to influenza vaccines than males. We hypothesized that female-biased immunity and protection would be dependent on the extent of virus diversity as well as molecular mechanisms in B cells which constrain the breadth of epitope recognition.</jats:p>
  • Zugangsstatus: Freier Zugang