Impaired Cytotoxic CD8+T Cell Response in Elderly COVID-19 Patients

Medientyp: E-Artikel
Titel: Impaired Cytotoxic CD8+T Cell Response in Elderly COVID-19 Patients
Beteiligte: Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc M.; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
Erschienen: American Society for Microbiology, 2020
Erschienen in: mBio
Sprache: Englisch
DOI: 10.1128/mbio.02243-20
ISSN: 2150-7511; 2161-2129
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Anmerkungen:
Beschreibung: <jats:p>Cytotoxic T cells are responsible for the elimination of infected cells and are key players in the control of viruses. CD8<jats:sup>+</jats:sup>T cells with an effector phenotype express cytotoxic molecules and are able to perform target cell killing. COVID-19 patients with a mild disease course were analyzed for the differentiation status and cytotoxic profile of CD8<jats:sup>+</jats:sup>T cells. SARS-CoV-2 infection induced a vigorous cytotoxic CD8<jats:sup>+</jats:sup>T cell response. However, this cytotoxic profile of T cells was not detected in COVID-19 patients over the age of 80 years. Thus, the absence of a cytotoxic response in elderly patients might be a possible reason for the more frequent severity of COVID-19 in this age group than in younger patients.</jats:p>
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