• Medientyp: E-Artikel
  • Titel: Effect of Subcutaneous Anti-CD20 Antibody-Mediated B Cell Depletion on Susceptibility to Pneumocystis Infection in Mice
  • Beteiligte: Dai, Guixiang; Noell, Kristin; Weckbecker, Gisbert; Kolls, Jay K.
  • Erschienen: American Society for Microbiology, 2021
  • Erschienen in: mSphere
  • Sprache: Englisch
  • DOI: 10.1128/msphere.01144-20
  • ISSN: 2379-5042
  • Schlagwörter: Molecular Biology ; Microbiology
  • Entstehung:
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  • Beschreibung: <jats:p> Anti-CD20 antibody therapy is used for both cancer and autoimmune disease but has been shown to be associated with <jats:named-content content-type="genus-species">Pneumocystis</jats:named-content> pneumonia in humans. This study shows that low-dose subcutaneous anti-CD20 can modulate B cell populations without grossly perturbing fungal immunity against <jats:named-content content-type="genus-species">Pneumocystis</jats:named-content> lung infection. </jats:p>
  • Zugangsstatus: Freier Zugang