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Anastasopoulou, Stavroula; Svensson, Eva; Wickström, Ronny; Hertting, Olof; Rinder, Malin Ryd; Bennet, Rutger; Eriksson, Margareta

Seizures in hospitalised paediatric patients with SARS-CoV-2 and comparison of severity with seizures in hospitalised paediatric patients with other respiratory viruses during the COVID-19 pandemic: a population-based cohort study

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  • Medientyp: E-Artikel
  • Titel: Seizures in hospitalised paediatric patients with SARS-CoV-2 and comparison of severity with seizures in hospitalised paediatric patients with other respiratory viruses during the COVID-19 pandemic: a population-based cohort study
  • Beteiligte: Anastasopoulou, Stavroula; Svensson, Eva; Wickström, Ronny; Hertting, Olof; Rinder, Malin Ryd; Bennet, Rutger; Eriksson, Margareta
  • Erschienen: BMJ, 2024
  • Erschienen in: Archives of Disease in Childhood
  • Sprache: Englisch
  • DOI: 10.1136/archdischild-2023-325974
  • ISSN: 0003-9888; 1468-2044
  • Schlagwörter: Pediatrics, Perinatology and Child Health
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec><jats:title>Objective</jats:title><jats:p>To study seizures in patients hospitalised due to SARS-CoV-2 infection, and compare their severity with seizures in patients hospitalised due to other viral respiratory tract infections (RTIs).</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>Observational population-based cohort study.</jats:p></jats:sec><jats:sec><jats:title>Setting</jats:title><jats:p>Northern Stockholm.</jats:p></jats:sec><jats:sec><jats:title>Patients</jats:title><jats:p>Patients aged 1 month–18 years hospitalised due to SARS-CoV-2 with and without seizures, and patients of the same age hospitalised due to other viral RTIs with seizures, between 1 March 2020 and 30 June 2022.</jats:p></jats:sec><jats:sec><jats:title>Main outcome measures</jats:title><jats:p>The prevalence of seizures in hospitalised patients due to SARS-CoV-2, the evaluation of assumed predictors of seizures and the comparison of severity markers in patients with SARS-CoV-2 versus other RTIs.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>32 of 239 included patients (13.4%) admitted due to SARS-CoV-2 infection had seizures. Central nervous system (CNS) disease and the omicron period had significantly increased OR for seizures (OR: 5.12; CI: 2.06 to 12.72 and OR: 3.01; CI: 1.15 to 7.88, respectively). Seizures in patients with SARS-CoV-2 were more common in children older than 5 years (p=0.001), even in the absence of fever (p=0.007), as compared with other viral RTIs. The duration of hospitalisation was longer in patients with seizures due to other viral RTIs (p=0.023). There was no significant difference regarding severity markers of seizures between the two groups.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>CNS disease and the omicron period were risk factors for seizures in patients with SARS-CoV-2, who were older than patients with other RTIs. The severity of seizures was comparable between the two groups; hospitalisation was however longer in patients with other RTIs.</jats:p></jats:sec>