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Abrahamyan, Sargis; Eberspächer, Bettina; Hoshi, Muna-Miriam; Aly, Lilian; Luessi, Felix; Groppa, Sergiu; Klotz, Luisa; Meuth, Sven G; Schroeder, Christoph; Grüter, Thomas; Tackenberg, Björn; Paul, Friedemann; Then-Bergh, Florian; Kümpfel, Tania; Weber, Frank; Stangel, Martin; Bayas, Antonios; Wildemann, Brigitte; Heesen, Christoph; Zettl, Uwe; Warnke, Clemens; Antony, Gisela; Hessler, Nicole; Wiendl, Heinz; [...]

Complete Epstein-Barr virus seropositivity in a large cohort of patients with early multiple sclerosis

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  • Medientyp: E-Artikel
  • Titel: Complete Epstein-Barr virus seropositivity in a large cohort of patients with early multiple sclerosis
  • Beteiligte: Abrahamyan, Sargis; Eberspächer, Bettina; Hoshi, Muna-Miriam; Aly, Lilian; Luessi, Felix; Groppa, Sergiu; Klotz, Luisa; Meuth, Sven G; Schroeder, Christoph; Grüter, Thomas; Tackenberg, Björn; Paul, Friedemann; Then-Bergh, Florian; Kümpfel, Tania; Weber, Frank; Stangel, Martin; Bayas, Antonios; Wildemann, Brigitte; Heesen, Christoph; Zettl, Uwe; Warnke, Clemens; Antony, Gisela; Hessler, Nicole; Wiendl, Heinz; [...]
  • Erschienen: BMJ, 2020
  • Erschienen in: Journal of Neurology, Neurosurgery & Psychiatry
  • Sprache: Englisch
  • DOI: 10.1136/jnnp-2020-322941
  • ISSN: 0022-3050; 1468-330X
  • Schlagwörter: Psychiatry and Mental health ; Neurology (clinical) ; Surgery
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec><jats:title>Objective</jats:title><jats:p>To determine the prevalence of antibodies to Epstein-Barr virus (EBV) in a large cohort of patients with early multiple sclerosis (MS).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Serum samples were collected from 901 patients with a clinically isolated syndrome (CIS) or early relapsing–remitting multiple sclerosis (RRMS) participating in the German National MS cohort, a prospective cohort of patients with early MS with stringent inclusion criteria. Epstein-Barr nuclear antigen (EBNA)-1 and viral capsid antigen (VCA) antibodies were measured in diluted sera by chemiluminescence immunoassays (CLIAs). Sera of EBNA-1 and VCA antibody-negative patients were retested undiluted by an EBV IgG immunoblot. For comparison, we retrospectively analysed the EBV seroprevalence across different age cohorts, ranging from 0 to &gt;80 years, in a large hospital population (N=16 163) from Berlin/Northern Germany.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>EBNA-1 antibodies were detected by CLIA in 839 of 901 patients with CIS/RRMS. Of the 62 patients without EBNA-1 antibodies, 45 had antibodies to VCA as detected by CLIA. In all of the remaining 17 patients, antibodies to EBV were detected by immunoblot. Altogether, 901 of 901 (100%) patients with CIS/RRMS were EBV-seropositive. EBV seropositivity increased with age in the hospital population but did not reach 100% in any of the investigated age cohorts.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The complete EBV seropositivity in this large cohort of patients with early MS strengthens the evidence for a role of EBV in MS. It also suggests that a negative EBV serology in patients with suspected inflammatory central nervous system disease should alert clinicians to consider diagnoses other than MS.</jats:p></jats:sec>