Beschreibung:
<jats:sec><jats:title>Introduction</jats:title><jats:p>Anosmia is a recognised risk factor for Parkinson’s disease (PD), however, many of the causes are not neurodegenerative. We hypothesise that the prodromal phase of PD associated with idiopathic anosmia is predominantly motor and does not have other significant non-motor features.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We recruited individuals with idiopathic anosmia (IA) (confirmed by specialist ENT assessment) from across England. Participants from the PREDICT-PD study who were deemed to be low risk of future PD on the basis of scoring with an evidence-based algorithm were used as healthy-aging controls (HA). Patients with established PD were recruited from clinic. All participants had a comprehensive in-person assessment.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We assessed 75 participants (HA=21, IA=40, PD=14), who were well balanced in terms of age and education. There were more men in the PD group than in the other two groups.</jats:p><jats:p>There was no difference in motor scores between the HA and IA groups in MDS-UPDRS-III scores (p=0.83), MOCA (p=0.06), RBDsq (p=0.39) or autonomic scores (p=0.20). When dividing IA into those with and without mild motor impairment (MMI; MDS-UPDRS-III ≥7), the IA-MMI group did not show overt non-motor differences compared to the HA group.</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>Some patients with IA present with motor dysfunction that is not associated with non-motor features. This has significance for understanding the variation in the prodromal phase of PD and poten- tially selecting patients for disease modifying trials.</jats:p><jats:p>richard.n.rees@ucl.ac.uk</jats:p></jats:sec>