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Medientyp:
E-Artikel
Titel:
Mice that lack astrotactin have slowed neuronal migration
Beteiligte:
Adams, Niels C.;
Tomoda, Toshifumi;
Cooper, Margaret;
Dietz, Gunnar;
Hatten, Mary E.
Erschienen:
The Company of Biologists, 2002
Erschienen in:
Development, 129 (2002) 4, Seite 965-972
Sprache:
Englisch
DOI:
10.1242/dev.129.4.965
ISSN:
0950-1991;
1477-9129
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>The cortical regions of the brain are laminated as a result of directed migration of precursor cells along glia during development. Previously, we have used an assay system to identify astrotactin as a neuronal ligand for migration on glial fibers. To examine the function of astrotactin in vivo, we generated a null mutation by targeted gene disruption. The cerebella of astrotactin null mice are approximately 10% smaller than wild type. In vitro and in vivo cerebellar granule cell assays show a decrease in neuron-glial binding, a reduction in migration rates and abnormal development of Purkinje cells. Consequences of this are poorer balance and coordination. Thus, astrotactin functions in migration along glial processes in vivo, a process required for generating laminar structures and for the development of synaptic partner systems.</jats:p>