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Medientyp:
E-Artikel
Titel:
A vertebrate specific and essential role for sp7/osterix in osteogenesis revealed by gene knock-out in the teleost medaka
Beteiligte:
Yu, Tingsheng;
Graf, Martin;
Renn, Joerg;
Schartl, Manfred;
Larionova, Daria;
Huysseune, Ann;
Witten, Paul Eckhard;
Winkler, Christoph
Erschienen:
The Company of Biologists, 2016
Erschienen in:
Development (2016)
Sprache:
Englisch
DOI:
10.1242/dev.139550
ISSN:
1477-9129;
0950-1991
Entstehung:
Anmerkungen:
Beschreibung:
Sp7/osterix (osx) encodes a zinc-finger transcription factor that controls osteoblast differentiation in mammals. Although identified in all vertebrate lineages, its role in non-mammalian bone formation remains elusive. Here we show that an osx mutation in medaka results in severe bone defects and larval lethality. Pre-osteoblasts fail to differentiate leading to severe intramembranous and perichondral ossification defects. The notochord sheath mineralizes normally supporting the idea of an osteoblast-independent mechanism for teleost vertebral centra formation. This study establishes a key role for Sp7/Osx for bone formation also in a non-mammalian species, and reveals conserved and non-conserved features in vertebrate bone formation.