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MARSHALL, RYAN N.; MORGAN, PAUL T.; SMEUNINX, BENOIT; QUINLAN, JONATHAN I.; BROOK, MATTHEW S.; ATHERTON, PHILIP J.; SMITH, KENNETH; WILKINSON, DANIEL J.; BREEN, LEIGH

Myofibrillar Protein Synthesis and Acute Intracellular Signaling with Elastic Band Resistance Exercise in Young and Older Men

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  • Medientyp: E-Artikel
  • Titel: Myofibrillar Protein Synthesis and Acute Intracellular Signaling with Elastic Band Resistance Exercise in Young and Older Men
  • Beteiligte: MARSHALL, RYAN N.; MORGAN, PAUL T.; SMEUNINX, BENOIT; QUINLAN, JONATHAN I.; BROOK, MATTHEW S.; ATHERTON, PHILIP J.; SMITH, KENNETH; WILKINSON, DANIEL J.; BREEN, LEIGH
  • Erschienen: Ovid Technologies (Wolters Kluwer Health), 2023
  • Erschienen in: Medicine & Science in Sports & Exercise, 55 (2023) 3, Seite 398-408
  • Sprache: Englisch
  • DOI: 10.1249/mss.0000000000003061
  • ISSN: 1530-0315; 0195-9131
  • Schlagwörter: Physical Therapy, Sports Therapy and Rehabilitation ; Orthopedics and Sports Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>ABSTRACT</jats:title> <jats:sec> <jats:title>Purpose</jats:title> <jats:p>Resistance exercise training (RET) attenuates age-related muscle and strength loss (“sarcopenia”). However, compared with machine-based RET, the efficacy of cost-effective, accessible elastic band RET (EB-RET) for muscle adaptive remodeling lacks supporting mechanistic evidence.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Eight young (YM; 24 ± 4 yr) and eight older (OM; 68 ± 6 yr) untrained males consumed an oral stable isotope tracer (D<jats:sub>2</jats:sub>O) combined with serial vastus lateralis muscle biopsies to measure integrated myofibrillar protein synthesis (iMyoPS) and regulatory signaling over ~48 h before (habitual) and after an acute bout of EB-RET (6 × 12 repetitions at ~70% of one-repetition maximum). iMyoPS was determined via gas chromatography–pyrolysis–isotope ratio mass spectroscopy and regulatory signaling expression by immunoblot.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Habitual iMyoPS did not differ between YM and OM (1.62% ± 0.21% vs 1.43% ± 0.47%·d<jats:sup>−1</jats:sup>, respectively, <jats:italic toggle="yes">P</jats:italic> = 0.128). There was a significant increase in iMyoPS after EB-RET in YM (2.23% ± 0.69%·d<jats:sup>−1</jats:sup>, <jats:italic toggle="yes">P</jats:italic> = 0.02), but not OM (1.75% ± 0.54%·d<jats:sup>−1</jats:sup>, <jats:italic toggle="yes">P</jats:italic> = 0.30). EB-RET increased the phosphorylation of key anabolic signaling proteins similarly in YM and OM at 1 h postexercise, including p-IRS-1<jats:sup>Ser636/639</jats:sup>, p-Akt<jats:sup>Ser473</jats:sup>, p-4EBP-1<jats:sup>Thr37/46</jats:sup>, p-P70S6K<jats:sup>Thr389</jats:sup>, and p-RPS6<jats:sup>Ser240/244</jats:sup>, whereas p-TSC2<jats:sup>Thr1462</jats:sup> and p-mTOR<jats:sup>Ser2448</jats:sup> increased only in YM (all <jats:italic toggle="yes">P</jats:italic> &lt; 0.05). There were no differences in the expression of amino acid transporters/sensors or proteolytic markers after EB-RET.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>iMyoPS was elevated after EB-RET in YM but not OM. However, the increase in acute anabolic signaling with EB-RET was largely similar between groups. In conclusion, the capacity for EB-RET to stimulate iMyoPS may be impaired in older age. Further work may be necessary to optimize prescriptive programming in YM and OM.</jats:p> </jats:sec>
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