An updated version of the Madagascar periwinkle genome

Medientyp: E-Artikel

Titel: An updated version of the Madagascar periwinkle genome

Beteiligte: Cuello, Clément; Stander, Emily Amor; Jansen, Hans J.; Dugé De Bernonville, Thomas; Oudin, Audrey; Birer Williams, Caroline; Lanoue, Arnaud; Giglioli Guivarc'h, Nathalie; Papon, Nicolas; Dirks, Ron P.; Jensen, Michael Krogh; O'Connor, Sarah Ellen; Besseau, Sébastien; Courdavault, Vincent

Erschienen: F1000 Research Ltd, 2022

Sprache: Englisch

DOI: 10.12688/f1000research.129212.1

ISSN: 2046-1402

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Beschreibung: <ns3:p>The Madagascar periwinkle, <ns3:italic>Catharanthus roseus</ns3:italic>, belongs to the <ns3:italic>Apocynaceae</ns3:italic> family. This medicinal plant, endemic to Madagascar, produces many important drugs including the monoterpene indole alkaloids (MIA) vincristine and vinblastine used to treat cancer worldwide. Here, we provide a new version of the <ns3:italic>C. roseus</ns3:italic> genome sequence obtained through the combination of Oxford Nanopore Technologies long-reads and Illumina short-reads. This more contiguous assembly consists of 173 scaffolds with a total length of 581.128 Mb and an N50 of 12.241 Mb. Using publicly available RNAseq data, 21,061 protein coding genes were predicted and functionally annotated. A total of 42.87% of the genome was annotated as transposable elements, most of them being long-terminal repeats. Together with the increasing access to MIA-producing plant genomes, this updated version should ease evolutionary studies leading to a better understanding of MIA biosynthetic pathway evolution.</ns3:p>

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