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Medientyp:
E-Artikel
Titel:
Filaments and phenotypes: cellular roles and orphan effects associated with mutations in cytoplasmic intermediate filament proteins
Beteiligte:
Klymkowsky, Michael W.
Erschienen:
F1000 Research Ltd, 2019
Erschienen in:
F1000Research, 8 (2019), Seite 1703
Sprache:
Englisch
DOI:
10.12688/f1000research.19950.1
ISSN:
2046-1402
Entstehung:
Anmerkungen:
Beschreibung:
Cytoplasmic intermediate filaments (IFs) surround the nucleus and are often anchored at membrane sites to form effectively transcellular networks. Mutations in IF proteins (IFps) have revealed mechanical roles in epidermis, muscle, liver, and neurons. At the same time, there have been phenotypic surprises, illustrated by the ability to generate viable and fertile mice null for a number of IFp-encoding genes, including vimentin. Yet in humans, the vimentin (VIM) gene displays a high probability of intolerance to loss-of-function mutations, indicating an essential role. A number of subtle and not so subtle IF-associated phenotypes have been identified, often linked to mechanical or metabolic stresses, some of which have been found to be ameliorated by the over-expression of molecular chaperones, suggesting that such phenotypes arise from what might be termed “orphan” effects as opposed to the absence of the IF networkper se, an idea originally suggested by Toivolaet al. and Pekny and Lane.