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Medientyp:
E-Artikel
Titel:
Performance Guarantees and Optimal Purification Decisions for Engineered Proteins
Beteiligte:
Martagan, Tugce;
Krishnamurthy, Ananth;
Leland, Peter A.;
Maravelias, Christos T.
Erschienen:
Institute for Operations Research and the Management Sciences (INFORMS), 2018
Erschienen in:
Operations Research, 66 (2018) 1, Seite 18-41
Sprache:
Englisch
DOI:
10.1287/opre.2017.1661
ISSN:
0030-364X;
1526-5463
Entstehung:
Anmerkungen:
Beschreibung:
We investigate protein purification operations conducted by biomanufacturers and pharmaceutical companies as part of their research and development efforts. Purification of these proteins involves unique challenges such as balancing the yield and purity trade-offs, dealing with uncertainty in the starting material, and estimating the impact of several interlinked decisions. We develop a Markov decision model and partition the state space into decision zones that provide managerial insights to optimize purification operations. We develop practical guidelines to quantify financial risks, and we characterize the optimal operating decisions based on specific production requirements. The optimization framework has been implemented at Aldevron, a contract biomanufacturer specializing in proteins, and has resulted in 25% reduction in the total lead times and 20% reduction in the costs of protein purification operations on average.