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Medientyp:
E-Artikel
Titel:
Modern Therapy of Acute Lymphoblastic Leukemia
Beteiligte:
Bassan, Renato;
Hoelzer, Dieter
Erschienen:
American Society of Clinical Oncology (ASCO), 2011
Erschienen in:
Journal of Clinical Oncology, 29 (2011) 5, Seite 532-543
Sprache:
Englisch
DOI:
10.1200/jco.2010.30.1382
ISSN:
0732-183X;
1527-7755
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p> Although acute lymphoblastic leukemia is curable in one third of adult patients, results vary greatly on account of different clinical, immunologic, and cytogenetic/genetic characteristics. These data, along with the kinetics of response to early treatment, help establish the individual risk class with considerable accuracy, and support risk-specific treatments that should warrant optimal results with as little as possible nonrelapse mortality. Modern first-line therapy consists of standard- and high-dose chemotherapy (increasingly inspired to pediatric principles), hematopoietic stem-cell transplantation, and new targeted therapy, all integrated with the analysis of prognostic factors and the study of subclinical residual disease for key therapeutic decisions. These changes are improving long-term outcome, which in ongoing studies is expected close to 50% or greater. </jats:p>