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Mizrak Kaya, Dilsa; Nogueras-Gonzalez, Graciela M.; Harada, Kazuto; Blum Murphy, Mariela A.; Das, Prajnan; Minsky, Bruce D.; Estrella, Jeannelyn; Lin, Quan; Ghazanfari Amlashi, Fatemeh; Lee, Jeffrey H; Weston, Brian; Bhutani, Manoop S.; Wu, Carol C; Matamoros, Aurelio; Sagebiel, Tara L.; Mansfield, Paul F.; Badgwell, Brian D.; Ajani, Jaffer A.

Risk of peritoneal carcinomatosis in localized gastric adenocarcinoma patients who undergo preoperative therapy and attempted surgery

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  • Medientyp: E-Artikel
  • Titel: Risk of peritoneal carcinomatosis in localized gastric adenocarcinoma patients who undergo preoperative therapy and attempted surgery
  • Beteiligte: Mizrak Kaya, Dilsa; Nogueras-Gonzalez, Graciela M.; Harada, Kazuto; Blum Murphy, Mariela A.; Das, Prajnan; Minsky, Bruce D.; Estrella, Jeannelyn; Lin, Quan; Ghazanfari Amlashi, Fatemeh; Lee, Jeffrey H; Weston, Brian; Bhutani, Manoop S.; Wu, Carol C; Matamoros, Aurelio; Sagebiel, Tara L.; Mansfield, Paul F.; Badgwell, Brian D.; Ajani, Jaffer A.
  • Erschienen: American Society of Clinical Oncology (ASCO), 2017
  • Erschienen in: Journal of Clinical Oncology
  • Sprache: Englisch
  • DOI: 10.1200/jco.2017.35.4_suppl.104
  • ISSN: 0732-183X; 1527-7755
  • Schlagwörter: Cancer Research ; Oncology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p> 104 </jats:p><jats:p> Background: Positive peritoneal cytology (+PCyt) or gross peritoneal carcinomatosis (GPC) carries a poor prognosis. Laparoscopic staging to detect +PCyt/GPC is recommended for all ≥T1b GACs. The natural history of GAC patients who have baseline –PCyt and then undergo multimodality therapy is not well documented, particularly for the risk of subsequent GPC. Methods: We analyzed 178 GAC patients with -PCyt at baseline who were followed postoperatively. Results: Of 178 patients who went to surgery after preoperative therapy, surgery in 14 patients (7.9%) was aborted due to GPC in 13 patients, and liver metastases in 1. We then analyzed 164 patients who had an R0 resection. The median follow-up duration was 3.4 (0.6-18) years. The rate of subsequent GPC was 13.4%, (22/164 patients) and the median time to GPC was 15.6 months. The median overall survival (OS) after GPC was only 7.1 months (95% CI: 0.4-17.9 months). Various clinical variables were related with GPC after an R0 resection (Table 1). The 5-year OS rate for patients without subsequent GPC was 75%. Conclusions: Even with baseline –PCyt, subsequent risk for GPC is ~20% in the best group of localized GAC patients. Patients who do not develop GPC have an excellent (75%) OS rate. Further research is warranted to identify patients at high risk of subsequent GPC. [Table: see text] </jats:p>
  • Zugangsstatus: Freier Zugang