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Carlomagno, Francesco; Pozza, Carlotta; Tenuta, Marta; Pofi, Riccardo; Tarani, Luigi; Sesti, Franz; Minnetti, Marianna; Gianfrilli, Daniele; Isidori, Andrea M

Testicular Microvascular Flow Is Altered in Klinefelter Syndrome and Predicts Circulating Testosterone

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  • Medientyp: E-Artikel
  • Titel: Testicular Microvascular Flow Is Altered in Klinefelter Syndrome and Predicts Circulating Testosterone
  • Beteiligte: Carlomagno, Francesco; Pozza, Carlotta; Tenuta, Marta; Pofi, Riccardo; Tarani, Luigi; Sesti, Franz; Minnetti, Marianna; Gianfrilli, Daniele; Isidori, Andrea M
  • Erschienen: The Endocrine Society, 2022
  • Erschienen in: The Journal of Clinical Endocrinology & Metabolism
  • Sprache: Englisch
  • DOI: 10.1210/clinem/dgab605
  • ISSN: 0021-972X; 1945-7197
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Context</jats:title> <jats:p>Experimental studies on Klinefelter syndrome (KS) reported increased intratesticular testosterone (T) levels coexisting with reduced circulating levels. Abnormalities in testicular microcirculation have been claimed; however, no studies investigated in vivo testicular blood flow dynamics in humans with KS.</jats:p> </jats:sec> <jats:sec> <jats:title>Objective</jats:title> <jats:p>To analyze the testicular microcirculation in KS by contrast-enhanced ultrasonography (CEUS) and correlate vascular parameters with endocrine function.</jats:p> </jats:sec> <jats:sec> <jats:title>Design and Setting</jats:title> <jats:p>Prospective study. University setting.</jats:p> </jats:sec> <jats:sec> <jats:title>Patients</jats:title> <jats:p>Sixty-eight testicular scans, 34 testes from 19 T-naïve subjects with KS and 34 testes from age-matched eugonadal men (control) who underwent CEUS for incidental nonpalpable testicular lesions.</jats:p> </jats:sec> <jats:sec> <jats:title>Main Outcomes</jats:title> <jats:p>CEUS kinetic parameters.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>CEUS revealed slower testicular perfusion kinetics in subjects with KS than in age-matched controls. Specifically, the wash-in time (P = 0.018), mean transit time (P = 0.035), time to peak (P &amp;lt; 0.001), and wash-out time (P = 0.004) were all prolonged. Faster testicular blood flow was associated with higher total T levels. Principal component analysis and multiple linear regression analyses confirmed the findings and supported a role for reduced venous blood flow as independent predictor of total T levels.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Testicular venous blood flow is altered in KS and independently predicts T peripheral release.</jats:p> </jats:sec>
  • Zugangsstatus: Freier Zugang