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Medientyp:
E-Artikel
Titel:
Serum miR-34a-5p and miR-199a-3p as new biomarkers of neonatal sepsis
Beteiligte:
Abdelaleem, Omayma O.;
Mohammed, Shereen Rashad;
El Sayed, Hassan S.;
Hussein, Sherin Khamis;
Ali, Doaa Y.;
Abdelwahed, Mostafa Y.;
Gaber, Sylvana N.;
Hemeda, Nada F.;
El-Hmid, Rehab G. Abd
Erschienen:
Public Library of Science (PLoS), 2022
Erschienen in:PLOS ONE
Sprache:
Englisch
DOI:
10.1371/journal.pone.0262339
ISSN:
1932-6203
Entstehung:
Anmerkungen:
Beschreibung:
<jats:sec id="sec001">
<jats:title>Background</jats:title>
<jats:p>Neonatal sepsis is a serious condition. Recent clinical studies have indicated that microRNAs (miRNAs) are key players in the pathogenesis of sepsis, which could be used as biomarkers for this condition.</jats:p>
</jats:sec>
<jats:sec id="sec002">
<jats:title>Patients and methods</jats:title>
<jats:p>A total of 90 neonates with sepsis and 90 healthy neonates were enrolled in this study. qRT-PCR was performed to measure the expression levels of serum miR-34a-5p and miR-199a-3p.</jats:p>
</jats:sec>
<jats:sec id="sec003">
<jats:title>Results</jats:title>
<jats:p>miR-34a-5p and miR-199a-3p serum levels were significantly reduced in neonates with sepsis compared with those in healthy neonates (P = 0.006 and P = 0.001, respectively). Significant correlations of miR-34a-5p and miR-199a-3p with each of TLC, RDW, RBS, and C-reactive protein (CRP) as well as SNAPII were observed, indicating their associations with the severity of neonatal sepsis.</jats:p>
</jats:sec>
<jats:sec id="sec004">
<jats:title>Conclusion</jats:title>
<jats:p>miR-34a-5p and miR-199a-3p may be useful as novel biomarkers in neonatal sepsis and may provide a new direction for its treatment.</jats:p>
</jats:sec>