Berg, Anders H;
Powe, Camille E;
Evans, Michele K;
Wenger, Julia;
Ortiz, Guillermo;
Zonderman, Alan B;
Suntharalingam, Pirianthini;
Lucchesi, Kathryn;
Powe, Neil R;
Karumanchi, S Ananth;
Thadhani, Ravi I
24,25-Dihydroxyvitamin D3 and Vitamin D Status of Community-Dwelling Black and White Americans
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Medientyp:
E-Artikel
Titel:
24,25-Dihydroxyvitamin D3 and Vitamin D Status of Community-Dwelling Black and White Americans
Beteiligte:
Berg, Anders H;
Powe, Camille E;
Evans, Michele K;
Wenger, Julia;
Ortiz, Guillermo;
Zonderman, Alan B;
Suntharalingam, Pirianthini;
Lucchesi, Kathryn;
Powe, Neil R;
Karumanchi, S Ananth;
Thadhani, Ravi I
Erschienen:
Oxford University Press (OUP), 2015
Erschienen in:Clinical Chemistry
Sprache:
Englisch
DOI:
10.1373/clinchem.2015.240051
ISSN:
0009-9147;
1530-8561
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title>
<jats:sec>
<jats:title>BACKGROUND</jats:title>
<jats:p>24,25-Dihydroxyvitamin D [24,25(OH)2D] is a metabolite of 25-hydroxyvitamin D (25D). Blacks frequently have low total 25D without manifestations of vitamin D deficiency, suggesting that total serum 25D may incorrectly reflect vitamin D status in different racial groups. The ratio of serum 24,25(OH)2D to 25D [vitamin D metabolite ratio (VMR)] represents a new candidate biomarker for vitamin D status.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>METHODS</jats:title>
<jats:p>We measured 24,25(OH)2D3 and 25D3 by mass spectrometry in a random community cohort of black (n = 212) and white (n = 164) Americans to evaluate VMR as a marker for vitamin D status. We measured parathyroid hormone concentrations by immunoassay to compare VMR and 25D3 against a physiological indicator of vitamin D deficiency.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>RESULTS</jats:title>
<jats:p>Serum 24,25(OH)2D3 strongly correlated with 25D3 in both black and white study participants (r = 0.90, P &lt; 0.001 and r = 0.86, P &lt; 0.001 respectively). Blacks had lower mean 25D3 than whites [17.0 (7.8) vs 27.5 (11.3) ng/mL; 42.4 (19.5) vs 68.6 (28.2) nmol/L, P &lt; 0.001] and lower mean 24,25(OH)2D3 [2.1 (1.3) vs 3.6 (2.0) ng/mL; 5.1 (3.1) vs 8.7 (4.8) nmol/L, P &lt; 0.001]. In contrast to total 25D3 concentrations, mean VMR values were similar in blacks and whites [11.9 (4.0) vs 12.5 (3.4), P = 0.16, respectively] and were negatively correlated with parathyroid hormone concentrations in both races (rs = −0.26, P &lt; 0.001, and rs = −0.25, P &lt; 0.001, respectively).</jats:p>
</jats:sec>
<jats:sec>
<jats:title>CONCLUSIONS</jats:title>
<jats:p>Our results provide further evidence that measurement of total 25D for assessment of vitamin D status in patients of African descent deserves reevaluation and suggest that alternative measures such as VMR should be considered.</jats:p>
</jats:sec>