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Manfrin, Erminia; Remo, Andrea; Pancione, Massimo; Cannizzaro, Claudia; Falsirollo, Francesca; Pollini, Giovanni Paolo; Pellini, Francesca; Molino, Annamaria; Brunelli, Matteo; Vendraminelli, Roberto; Ceccarelli, Michele; Pagnotta, Stefano Maria; Simeone, Ines; Bonetti, Franco

Comparison Between Invasive Breast Cancer With Extensive Peritumoral Vascular Invasion and Inflammatory Breast Carcinoma

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  • Medientyp: E-Artikel
  • Titel: Comparison Between Invasive Breast Cancer With Extensive Peritumoral Vascular Invasion and Inflammatory Breast Carcinoma
  • Beteiligte: Manfrin, Erminia; Remo, Andrea; Pancione, Massimo; Cannizzaro, Claudia; Falsirollo, Francesca; Pollini, Giovanni Paolo; Pellini, Francesca; Molino, Annamaria; Brunelli, Matteo; Vendraminelli, Roberto; Ceccarelli, Michele; Pagnotta, Stefano Maria; Simeone, Ines; Bonetti, Franco
  • Erschienen: Oxford University Press (OUP), 2014
  • Erschienen in: American Journal of Clinical Pathology
  • Sprache: Englisch
  • DOI: 10.1309/ajcpoxkx67kraovm
  • ISSN: 1943-7722; 0002-9173
  • Schlagwörter: General Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Objectives:</jats:title> <jats:p>Extensive peritumoral neoplastic lymphovascular invasion (ePVI) is a marker of aggressiveness in invasive breast carcinoma (BC).</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>We explored the impact of ePVI on different BC subtypes. In a total of 2,116 BCs, 91 ePVI-BCs, 70 inflammatory breast carcinomas (IBCs), and 114 casual BCs as a control group (CG-BC) were recruited.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>Patients affected by ePVI-BC were younger, had larger tumors, higher histologic grade, elevated Ki-67 score, Her2/neu overexpressed, and more lymph node metastases compared with CG-BC (P &amp;lt; .001). Interestingly, only younger mean age at diagnosis differentiated patients with ePVI-BC from patients affected by IBC. ePVI-BC showed a clinical outcome intermediate between the prognoses of IBC and CG-BC.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>Results suggest that ePVI-BC and IBC may share some pathologic processes, providing a novel perspective on the heterogeneity of BC. Epidemiologic data and molecular studies on gene expression features are needed to rationally classify these tumors into their identified subtypes.</jats:p> </jats:sec>
  • Zugangsstatus: Freier Zugang