Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
20 years of RET/PTC in thyroid cancer: clinico-pathological correlations
Beteiligte:
Fusco, Alfredo;
Santoro, Massimo
Erschienen:
FapUNIFESP (SciELO), 2007
Erschienen in:
Arquivos Brasileiros de Endocrinologia & Metabologia, 51 (2007) 5, Seite 731-735
Sprache:
Nicht zu entscheiden
DOI:
10.1590/s0004-27302007000500010
ISSN:
0004-2730
Entstehung:
Anmerkungen:
Beschreibung:
The RET/PTC oncogene has been isolated almost twenty years ago. During these years, the research has given a final answer to several questions. In fact, it has been demonstrated that: a) RET/PTC is an early event in the process of thyroid carcinogenesis and has a critical role in the generation of the papillary carcinoma; b) RET/PTC activation is essentially restricted to the papillary histotype and to the Hürthle thyroid tumors; c) its incidence increases after exposure to radiations. However, some questions have not found a final answer yet: a) which is the real frequency of RET/PTC activation? Likely it is around 20%, but this point is still questionable; b) which other gene modifications are required to lead a thyroid cell carrying a RET/PTC oncogene to the malignant phenotype?, and c) is there any correlation between RET/PTC activation and clinical parameters? We hope that these questions will have a clear answer in the near future.