• Medientyp: E-Artikel
  • Titel: Die Bildung von Thymidintriphosphat bei Tetrahymena pyriformis (EHRENBERG) in statistischen und hitzesynchronisierten Kulturen / Formation of Thymidine Triphosphate in statistical and heat synchronized cultures of Tetrahymena pyriformis (EHRENBERG)
  • Beteiligte: Grieshaber, Manfred K.; Duspiva, Franz
  • Erschienen: Walter de Gruyter GmbH, 1970
  • Erschienen in: Zeitschrift für Naturforschung B
  • Sprache: Englisch
  • DOI: 10.1515/znb-1970-0515
  • ISSN: 1865-7117; 0932-0776
  • Schlagwörter: General Chemistry
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>The activity of thymidylate kinase is correlated with DNA-synthesis in Tetrahymena. During logarithmic growth it is twice as high as in the stationary phase; in cultures synchronized by heat treatment, the activity of the enzyme increases with the onset of DNA-synthesis. After application of 5 x 10<jats:sup>-6</jats:sup> ᴍ Methotrexate, the activity of thymidylate kinase remains unchanged. There is, however, a dramatic increase in enzyme activity when the inhibition of transmethylations is circumvened by adding thymidine and proteose-peptone.</jats:p>
  • Zugangsstatus: Freier Zugang