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Medientyp:
E-Artikel
Titel:
Concordance of Eight Kits for Antithyroid Peroxidase Autoantibodies Determination
Beteiligte:
d'Herbomez, Michèle;
Sapin, Rémy;
Gasser, Françoise;
Schlienger, Jean Louis;
Wémeau, Jean Louis
Erschienen:
Walter de Gruyter GmbH, 2000
Erschienen in:
cclm, 38 (2000) 6, Seite 561-566
Sprache:
Englisch
DOI:
10.1515/cclm.2000.082
ISSN:
1434-6621
Entstehung:
Anmerkungen:
Beschreibung:
Abstract Numerous methods are proposed to quantify antithyroid peroxidase autoantibodies. No standardization exists but most assays use the standard MRC 66/387 with a calibration factor. Costs of the tests vary between the different kits. We evaluated the concordance of eight peroxidase autoantibodies assay kits in two centres, using a panel of sera from 269 subjects: controls (n=100), patients with autoimmune thyroid disease (n=77; Graves' disease, Hashimoto's thyroiditis), patients with non-autoimmune thyroid disease (n=69; nodular goiter, differentiated thyroid carcinoma) and individual sera with thyroglobulin antibodies only (n=23). The concordance between the eight methods was high, ranging from 88.3% to 98.8% with the total panel of sera. The majority of assays demonstrated high diagnostic performance. We encountered some false-positive results at borderline positive levels, and the nonrecognition of some sera by competitive assays.