Marczyński, Zbigniew;
Nowak, Sławomira;
Jambor, Jerzy;
Zgoda, Marian Mikołaj
Solubility and solubilizing capabilities of aqueous solutions of Extractum Taraxaci e radix cum herba aqu. siccum in light of selected values of general Hildebrand-Scatchard-Fedors theory of solubility
Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Solubility and solubilizing capabilities of aqueous solutions of Extractum Taraxaci e radix cum herba aqu. siccum in light of selected values of general Hildebrand-Scatchard-Fedors theory of solubility
Beteiligte:
Marczyński, Zbigniew;
Nowak, Sławomira;
Jambor, Jerzy;
Zgoda, Marian Mikołaj
Erschienen:
Walter de Gruyter GmbH, 2016
Erschienen in:Herba Polonica
Sprache:
Englisch
DOI:
10.1515/hepo-2016-0022
ISSN:
2449-8343
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Summary</jats:title>
<jats:p>
<jats:bold>Introduction:</jats:bold> The general Hildebrand-Scatchard theory of solubility supplemented by Fedors’ solubility parameter <jats:inline-formula>
<jats:alternatives>
<jats:inline-graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/j_hepo-2016-0022_eq_001.png" />
<m:math xmlns:m="http://www.w3.org/1998/Math/MathML" display="inline">
<m:mrow>
<m:mo>−</m:mo>
<m:msup>
<m:mi>δ</m:mi>
<m:mrow>
<m:mfrac>
<m:mn>1</m:mn>
<m:mn>2</m:mn>
</m:mfrac>
</m:mrow>
</m:msup>
</m:mrow>
</m:math>
<jats:tex-math>$- \delta ^{{1 \over 2}} $</jats:tex-math>
</jats:alternatives>
</jats:inline-formula> was used to estimate the real solubility by −log x<jats:sub>2</jats:sub> (log of the mole fraction) of phytochemicals contained in <jats:italic>Ext. Taraxaci e radix cum herba aqu. siccum</jats:italic>. Surface activity of aqueous solution of extracts was determined and quantified – solubilizing capabilities of solutions of c<jats:sub>exp.</jats:sub> ≥cmc in relation to cholesterol particle size of Ø=1.00 mm, as well as of ketoprofen were defined.</jats:p>
<jats:p>
<jats:bold>Objective:</jats:bold> The calculated value −log x<jats:sub>2</jats:sub> collated with the polarity of extraction medium ε<jats:sub>M</jats:sub> allows to estimate the optimal solubility of phytochemicals that determine the viscosity of the aqueous extract of dandelion and above all its surface activity and the ability to solubilize lipophilic therapeutic agents (ketoprofen).</jats:p>
<jats:p>
<jats:bold>Methods:</jats:bold> Viscosity of water model solutions of dandelion extracts and exhibition solutions after the effective micellar solubilization of cholesterol and ketoprofen was measured using Ubbelohde viscometer in accordance with the Polish Standard. The surface tension of aqueous solutions of extract and exhibition solutions after solubilization of cholesterol and ketoprofen was measured according to the Polish Standard with stalagmometric method.</jats:p>
<jats:p>
<jats:bold>Results:</jats:bold> The calculated factual solubility, and mainly the determined and calculated hydrodynamic size mean, that despite the complex structure of the micelle, it solubilizes cholesterol (granulometric grain of diameter Ø=1.00 mm) and ketoprofen (state of technological fragmentation) in equilibrium conditions. Equilibrium solubilization of ketoprofen also occurs in an environment of model gastric juice (0.1 mol HCl).</jats:p>
<jats:p>
<jats:bold>Conclusions:</jats:bold> The obtained results indicate that after the administration (and/or dietary supplementation) with <jats:italic>Ext. Taraxaci e radix cum herba aqu. siccum</jats:italic>, the physiological parameters of gastric juice would not be measured and its presence (phytosurfactant) in the body of the duodenum (bile A) increases abilities of solubilizing lipophilic therapeutic agents and cholesterol accounting for its use in the treatment of liver diseases and cholesterol gall bladder stones.</jats:p>