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Medientyp:
E-Artikel
Titel:
Newtonoate as an active principle of Newtonia griffoniana for anxiolytic activity in Swiss mice
Beteiligte:
Djiogue, Sefirin;
Kinyok, Mc Jesus;
Ketcha Wanda, Germain Jean Magloire;
Zemo Gamo, Franklin;
Seke Etet, Paul Faustin;
Nwabo Kamdje, Armel Herve;
Pegnyemb, Dieudonné Emmanuel;
Njamen, Dieudonné
Erschienen:
Walter de Gruyter GmbH, 2015
Erschienen in:
Journal of Complementary and Integrative Medicine, 12 (2015) 4, Seite 283-287
Sprache:
Englisch
DOI:
10.1515/jcim-2015-0018
ISSN:
2194-6329;
1553-3840
Entstehung:
Anmerkungen:
Beschreibung:
Abstract Background: Newtonia griffoniana (Mimosaceae) is a Central African rain forest tree, whose bark extracts are used in Cameroonian folk medicine for the treatment of anxiety and sleep disorders. Methods: We evaluated the anxiolytic effects of N. griffoniana stem bark methanol extract and its major isolated constituent 2,3,4-trihydroxybutylpentatriacontanoate (newtonoate) on the elevated plus maze. Results: Significant increases in the percentage of entries into open arms were induced by both N. griffoniana extract (100 and 150 mg/kg BW; p<0.01) and newtonoate (doses of 3 and 15 mg/kg BW; p<0.05). Conversely, decreases in the percentage of entries into closed arms were observed at the same doses. In addition, N. griffoniana methanol extract (100 mg/kg) and the isolated newtonoate (30 mg/kg) induced significant (p<0.01 and p<0.05, respectively) increases in the time spent in the open arms, while inducing a decrease in the time spent in the closed arms. Newtonoate treatment also decreased head dipping number at doses of 3 and 15 mg/kg, while N. griffoniana methanol extract induced the same effect at 200 mg/kg. Conclusions: These results suggest that N. griffoniana bark extract has anxiolytic properties, which justify its use in folk medicine. Such effects are at least partly mediated by newtonoate.