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Frankel, Arthur E.; Flaherty, Keith T.; Weiner, George J.; Chen, Robert; Azad, Nilofer S.; Pishvaian, Michael J.; Thompson, John A.; Taylor, Matthew H.; Mahadevan, Daruka; Lockhart, A. Craig; Vaishampayan, Ulka N.; Berlin, Jordan D.; Smith, David C.; Sarantopoulos, John; Riese, Matthew; Saleh, Mansoor N.; Ahn, Chul; Frenkel, Eugene P.

Academic Cancer Center Phase I Program Development

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  • Medientyp: E-Artikel
  • Titel: Academic Cancer Center Phase I Program Development
  • Beteiligte: Frankel, Arthur E.; Flaherty, Keith T.; Weiner, George J.; Chen, Robert; Azad, Nilofer S.; Pishvaian, Michael J.; Thompson, John A.; Taylor, Matthew H.; Mahadevan, Daruka; Lockhart, A. Craig; Vaishampayan, Ulka N.; Berlin, Jordan D.; Smith, David C.; Sarantopoulos, John; Riese, Matthew; Saleh, Mansoor N.; Ahn, Chul; Frenkel, Eugene P.
  • Erschienen: Oxford University Press (OUP), 2017
  • Erschienen in: The Oncologist
  • Sprache: Englisch
  • DOI: 10.1634/theoncologist.2016-0409
  • ISSN: 1083-7159; 1549-490X
  • Schlagwörter: Cancer Research ; Oncology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:p>Multiple factors critical to the effectiveness of academic phase I cancer programs were assessed among 16 academic centers in the U.S. Successful cancer centers were defined as having broad phase I and I/II clinical trial portfolios, multiple investigator-initiated studies, and correlative science. The most significant elements were institutional philanthropic support, experienced clinical research managers, robust institutional basic research, institutional administrative efforts to reduce bureaucratic regulatory delays, phase I navigators to inform patients and physicians of new studies, and a large cancer center patient base. New programs may benefit from a separate stand-alone operation, but mature phase I programs work well when many of the activities are transferred to disease-oriented teams. The metrics may be useful as a rubric for new and established academic phase I programs.</jats:p>
  • Zugangsstatus: Freier Zugang